Targeting Three Spike Protein Domains Regulating SARS-CoV-2 Infectivity

John S. Kenney, Kurt DeShayes, Catherine Vo, Emmeline Truong, Rick Chang, Opel Arenas, Shyairra Dodd, Huda Abushanab, Ron Gamatero, Edgar Rodriguez, Glen Lin, Leonel Santibanez-Vargas, Emily Keshner, Keerthi Sindhu, and Joshua K. Lowitz

Introduction

In this research, we’ve described three unique functional domain-specific antibodies to the CoV-2 spike protein. Their fine specificity is shown by sensitivity of binding to different spike protein constructs. The ability of the antibodies to impact spike protein function is shown by inhibition of AC2 Binding, furin cleavage, and Pseudovirus infectivity. The antibodies can serve as tools to dissect the mechanism of SARS-CoV-2 infectivity and as potential leads for COVID-19 therapeutics.

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