Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms

Joshua Lowitz, Glen Lin, Jennifer Somera, Leonel Santibanez-Vargas, Catherine Vo, Edgar Rodriguez, Billy Nguyen, Michael Trang, John Nichols and John S. Kenney Antibody Solutions, Sunnyvale, CA, USA

Introduction:

Immunization of transgenic animals producing human antibodies has been the most successful approach to obtaining fully human therapeutic antibodies. They allow for the rapid generation of candidate antibodies to multiple targets of interest and the ability to transition lead candidates to clinical development without undergoing time consuming and costly steps such as humanization or affinity maturation of antibodies from structural display libraries.

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