Comparison of Animal-Derived Ab Platforms

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Animal-derived Ab platforms have generated 92% of the therapeutic Abs in use today. For fully human Abs, more than twice as many therapeutic Abs have ben generated from transgenic animals compared to recombinant libraries, which is an older technology.

 

Antibodies optimized naturally by an animals immune system have the advantages of:

  • inducible system driven by multiple in-vivo mechanisms of diversity
  • diversity through multiple species, strains, and immunization regimens
  • normal pairing of Heavy and Light chains
  • normal post-translational modification
  • normal secretion, no engineering for gene expression
  • no molecular engineering artifacts
  • natural elimination of unstable, immunogenic and autoimmune Abs

Human Phage-Display may have some but not all of these mechanisms.

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