Antibody Manufacturing
R&D Manufacturing
In custom antibody discovery, once lead selection is complete and it’s time to produce antibodies, a new set of dynamics quickly become key benchmarks: ”speed,” “scalability,” and “purity” are the mainstays that define success. In fact, this is when the quality of the process used in antibody production jumps to the top of the list.
![R&D manuf icon@3x-1 R&D manuf icon@3x-1](https://www.antibody.com/hs-fs/hubfs/R%26D%20manuf%20icon@3x-1.png?width=199&height=200&name=R%26D%20manuf%20icon@3x-1.png)
Production from Hybridoma
Available exclusively to Antibody Solutions clients, MAbExpress™ is a highly personalized, responsive and agile technology that, when combined with our commitment to process excellence, enables us to deliver the high-quality, R&D grade, fit-for-purpose antibodies that you need for your drug research or in vivo animal studies. Through MAbExpress™, your team can cut production timelines by:
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Generating a large quantity of the antibodies you need from a single lot, guaranteed by in-process monitoring
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Leveraging bioreactors to scale up research-grade output
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Securing production and purification for all antibody species (mouse, rat, human) and isotypes (IgG and IgM)
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Capitalizing on the proven success of a standard MAbExpress™ program on multiple scales that delivers on specs like:
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Fast turnaround to research-scale quantity of antibody
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Manufacture-scale quantities of antibody
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Quantities guaranteed by in-process monitoring
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Low endotoxin
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<0.1% Bovine IgG
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Very low protease, host DNA and RNAse
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High-purity antibodies for in vivo animal studies
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Faster. More reliable. Animal-friendly. All the best attributes you look for in antibody production are natural outcomes of the combination of our science-based approach and MAbExpress™.
Recombinant Antibody Production
Starting from a sequence? Antibody Solutions can employ its experience in recombinant expression to deliver purified antibodies for all your R&D needs.
Beginning with de novo gene synthesis and expression vector design, Antibody Solutions can ensure the highest quality starting material, including:
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Codon- optimized gene synthesis and cloning via Gibson assembly
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Multiple Species (human, mouse, rat, rabbit) including chimeric constructs
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Multiple isotypes (from IgG1 to IgG4)
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Custom mutations (Fc, knob-in-hole heterodimers, etc)
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Sequence verification and QC with low endotoxin plasmid preps
Equipped with the highest quality starting material, we can then proceed with recombinant antibody production and purification utilizing:
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Mammalian expression hosts (CHO or HEK)
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Optimized transfection system and harvest schedule
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Suspension cell cultures for high yield (up to >1 g)
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Option to generate stable cell line
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Manufacturing grade resins for antibody purification
Taking on the tough challenges together
Our hallmarks in antibody purification and production are aligned to exactly what our clients need most: reliability, timeliness, and cost-effectiveness. To learn more about our antibody manufacturing process and see how it may be an ideal match for your team’s needs, just contact us to get the conversation started.
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