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1 min read
Pathways to Antibody Discovery Using the Cellestive™ Platform
Cellestive™ leverages the success of immune rodents in raising diverse and developable Abs. It can interrogate and isolate different B-cell...
1 min read
Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders
Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female...
1 min read
Capturing the Functional Antibody Repertoire from Multiple B-cell Subsets Following Antigen Stimulation
B-cells are the original antibody display platform. Over time, they have proved to be the most reliable source of therapeutic antibodies. Capturing...
2 min read
Antibodies Targeting Three Spike Protein Domains Regulating SARS-CoV-2 Infectivity
Infectivity of SARS-CoV-2 is regulated by three sites on the spike protein: a receptor binding motif (RBM), a subunit (S)1/S2 cleavage site acted...
1 min read
Development of a Defined Cloning and Growth Factor Formulation for Murine Hybridomas
Conditioned media from cultured cells have long been used to increase the cloning efficiency, growth rate and antibody secretion of hybridomas. The...
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Generation of Antibodies to Difficult Membrane Protein Targets
Multipass transmembrane and multimeric membrane proteins are targets for the development of therapeutic monoclonal antibodies, but they present...
1 min read
Antibody targeting functional domains of the SARS-CoV-2 Spike protein
Infectivity of SARS-CoV-2 is regulated by three sites on the spike protein: a receptor binding motif (RBM), a subunit (S)1/S2 cleavage site acted...
1 min read
Development of human antibodies to human vascular endothelial growth factor -C (VEGF-C) and -D (VEGF-D)
Recent studies have suggested a link between the growth of cysts found in the lungs of patients with lymphangioleiomyomatosis (LAM) and elevated...
1 min read
Generation of Neutralizing Human Monoclonal Antibodies Against a Therapeutic Target from the Alloy Therapeutics Mouse
Immunization of transgenic animals producing human antibodies is the most successful approach to obtaining fully human therapeutic antibodies. They...