Transgenic Animals

Modeled For Efficiency

Since the first transgenic mouse was created in 1974, scientists have sought to capitalize fully on the promise transgenic animals offer to cut the time and cost of antibody discovery. After all, human antibody producing transgenic animals have the advantage of generating fully human antibody variable domains that can be easily converted to fully human antibodies, while conventional animals require the extra time and effort involved in humanization.

Evaluating whether to use conventional animals alone or to incorporate human antibody-producing transgenic platforms into your research could impact your discovery timeline. Each platform requires a tailored approach that demands deep experience and an understanding that the best practices for antibody discovery – such as immunization protocols, tailored reagents, and data interpretation – can differ for each platform.

Pairing the Right Model with the Right Program

We know your choice of animal model may not rest solely on the science side of things; there are always other factors involved (not the least of which is program budgets). We were one of the first companies to use humanized transgenic animals when they became available to contract research organizations in 2012, and have since successfully immunized hundreds of cohorts of humanized transgenic animals. It’s a highly specialized – and increasingly important – experience that few can match.

Today, we’re one of the few, if only, companies having worked with all of the available transgenic animal platforms on a non-exclusive basis. We’ve found considerable advantages for antibody research in all of them; in fact, you can see firsthand how we compare them in this study. And when you’re ready to start, we have established relationships with the industry’s premier transgenic animal providers, such as Alloy Therapeutics and OmniAb, and can help you leverage the benefits of their scientific expertise and technology.

A Trusted, Unbiased Partner in Leveraging Transgenic Platforms

If an existing transgenic rodent platform isn’t an ideal choice for your research, we’re ready to explore how other technologies may provide a better fit. In addition, we can assist you with any unique animal platforms that are proprietary to your organization.

That’s why our clients trust Antibody Solutions. They depend on us to help them evaluate their best alternatives from a continually growing array of choices, including their own platforms. Our mission to develop successful fit-for-purpose antibodies begins both with a clear understanding of your purpose and the business dynamics shaping your research pipeline, and not from a pre-prescribed vantage point that points automatically toward one platform over another.

Enlist the Support of an Experienced Team

By picking the right transgenic animal platform — and then coupling it with our proven process for designing and coordinating successful antibody generation campaigns — Antibody Solutions helps you optimize both the efficiency and effectiveness of your discovery initiatives. We’d welcome the opportunity to support your next campaign, so please get in touch with us today to start the conversation.

Let our accomplishments
work for you

We’ve found considerable advantages for antibody research in all of these platforms (in fact, you can see firsthand how we compare them in this study). If one of these transgenic rodent platforms isn’t an ideal choice for your research, we’re ready to explore how other technologies may provide a better fit. In addition, we are ready to assist you with any unique animal platforms that are proprietary to your organization.